abstract：:The statistical distribution of colony counts in the spleen colony assay was determined in C57BL/6 and C3H mice under varying conditions of the assay procedure. Assay mice were given syngeneic bone marrow cells from normal or irradiated donors. The mice were injected intravenously with marrow cells either immediately ...

journal_title：Experimental hematology

authors： Mossman KL

更新日期：1977-11-01 00:00:00

abstract：:Haemopoietic regeneration was studied following x-irradiation and transplantation of bone marrow from either normal or hydroxyurea-treated donor mice, to ascertain the contribution of proliferating progenitor cells to regeneration. With transplantation of equivalent numbers of CFU-S, total DNA and 3HTdR uptake into DN...

journal_title：Experimental hematology

authors： Hasthorpe S,Hodgson GS

更新日期：1977-09-01 00:00:00

abstract：:To investigate the effect of interferon on the proliferation of normal erythroid precursor cells, various interferon preparations were added to mouse fetal liver cells cultured in a liquid microculture system. The effect of interferon was studied using cellular tritiated thymidine incorporation both in the presence an...

journal_title：Experimental hematology

authors： Smith KA,Fredrickson TN,Mobraaten LE,DeMaeyer E

更新日期：1977-09-01 00:00:00

abstract：:Rats made transiently neutropenic by intra-arterial administration of vinblastine (3 mg/kg) and infected with E. coli (6.02+/-0.45 X 10(8), per animal) have a mortality rate of 90% within 48 h post infection. Multiple transfusions of large numbers of granulocytes (harvested from Deca-Durabolin treated donor rats) prot...

journal_title：Experimental hematology

authors： Popovic V,Schaffer R,Popovic P

更新日期：1977-05-01 00:00:00

abstract：:Between 30 and 40% of the CSF present in agar was depleted after culture for 1 week with 50,000 nucleated murine bone marrow cells. No statistically significant difference could be detected between this depletion and the extent of depletion of CSF when the amount present was halved. There was no evidence that toxic or...

journal_title：Experimental hematology

authors： Rosendaal M

更新日期：1977-03-01 00:00:00

abstract：:An 18-year-old male with severe aplastic anemia associated with hepatitis was prepared for bone marrow transplantation with cyclophosphamide (50 mg/kg/day) for 4 consecutive days. He then received 3.47 X 10(8) nucleated bone marrow cells per kilogram of body weight from his HL-A identical sister by intravenous infusio...

journal_title：Experimental hematology

authors： Sensenbrenner LL,Steele AA,Santos GW

更新日期：1977-01-01 00:00:00

abstract：:This study is about enrichment of hemopoietic stem cell concentration in mouse bone marrow by use of a glass wool filtration technique. Maximum stem cell concentration was accomplished when filtration conditions were as follows: (1) support medium supplemented to 15% with fresh serum from syngeneic donors; (2) no incu...

journal_title：Experimental hematology

authors： Davis ML,Woodard DA,Pesto M,Toya RE

更新日期：1977-01-01 00:00:00

abstract：:In vitro treatment of parental C57BL/6 lymphohematopoietic cell grafts with unabsorbed guinea pig anti-mouse thymocyte serum (ATS) and guinea pig complement (GPC), prior to inoculation into lethally irradiated B6D2F hybrid hosts, has proven to be of value in terms of mitigating graft-versus-host disease (GvHD). Howeve...

journal_title：Experimental hematology

authors： Volf D,Sensenbrenner LL,Santos GW

更新日期：1976-11-01 00:00:00

abstract：:Specific changes taking place in the erythroid tissue following depletion or replacement of androgens were studied in rats. The reduction of testosterone levels in blood of orchiectomized animals did occur in conjunction with a decline of erythrocyte glucose-6-phosphate (G6P) and lactate levels. No evidence of anemia ...

journal_title：Experimental hematology

authors： Molinari PF,Esber HJ,Snyder LM

更新日期：1976-09-01 00:00:00

abstract：:The use of neonatal instead of fetal calf serum, as a constituent of the culture medium, confronted the authors with the problem of toxicity in the fetal liver cell erythropoietin assay. Tested human sera were toxic at rather low concentrations. Heating the human sera for 30 min at 56 degrees C abolished the toxicity....

journal_title：Experimental hematology

authors： von Preyss B,Goudsmit R

更新日期：1976-05-01 00:00:00

abstract：:A reliable dose-response curve has been established by exposing normal mice to graded doses of exogenous erythropoietin (ESF). In CF1 femal mice, made polycythemic by exposure to reduced air pressure , 59 Fe incorporation in RBC following injections of ESF (ranging from 0.05 to 3.2 IRP-units) varied according to the...

journal_title：Experimental hematology

authors： Bozzini CE,Alvarez Ugarte CA,Martínez MA,Soriano G,Alippi RM,Giglio MJ

更新日期：1976-03-01 00:00:00

abstract：:Peripheral blood lymphocytes obtained at 24-30 months after birth from a male with X-linked severe combined immune deficiency maintained in a gnotobiotic environment were characterized by T and B cell surface markers. A high proportion (55-80 percent) of circulating lymphocytes bore surface IgM as detected by direct i...

journal_title：Experimental hematology

authors： Mukhopadhyay N,Richie E,Montgomery J,Wilson R,Fernbach DJ,South MA

更新日期：1976-01-01 00:00:00

abstract：:Two main aspects of the in vitro mouse foetal liver cell assay for Erythroid Stimulating Factor (ESF) in human sera have been investigated. The haem extraction process has been shown to give specific and quantitative recovery of 59Fe labelled haem from haemoglobin thus confirming that the material assayed in human ser...

journal_title：Experimental hematology

authors： Dunn CD,Napier JA

更新日期：1975-11-01 00:00:00

abstract：:Exposure to low levels of x-irradiation (50R) followed by phlebotomy (50% blood volume) one month post-irradiation, resulted in identifiable alterations of the erythropoietic status of the rat. The red cell indices revealed a decrease in mean corpuscular volume and an increase in mean corpuscular hemoglobin concentrat...

journal_title：Experimental hematology

authors： Marchetti DL,Glomski CA

更新日期：1975-11-01 00:00:00

abstract：:Mouse bone marrow cells were cultured to determine some basic characteristics of the diffusion chamber (DC) technique. The main findings were as follows: (i) Incorporated 3H-thymidine was conveniently measured after deposition of a cell sample on glass fibre discs followed by methanol washing. Varying the specific act...

journal_title：Experimental hematology

authors： Benestad HB,Reikvam A

更新日期：1975-08-01 00:00:00

abstract：:Addition of serum or plasma from many species increased the number and size of neutrophilic granulocyte and macrophage colonies formed in vitro by mouse bone marrow cells after stimulation by a variety of preparations containing colony stimulating factor (CSF). The active factor in serum was heat-labile, non-dialyzabl...

journal_title：Experimental hematology

authors： Metcalf D,MacDonald HR,Chester HM,Metcalf D,MacDonald HR,Chester HM

更新日期：1975-08-01 00:00:00

abstract：:Quantitative measurements on the haemopoiedic systems of SAS/4, 3H and RFM mice have been used to calculate the distribution and population sizes of haemopoietic cells in the bone marrow, spleen and peripheral blood. Considerable strain differences have been found in the sizes of haemopioetic stem cell populations and...

journal_title：Experimental hematology

authors： Coggle JE,Gordon MY

更新日期：1975-06-01 00:00:00

abstract：:Twenty-five dogs with malignant lymphoma (L) and 18 dogs with solid, nonhematologic tumors (ST) were treated with 1200 R total body irradiation (TBI). Rescue from the otherwise lethal hemopoietic toxicity by infusion of autologous marrow aspirated before TBI was attempted, and survival, response to TBI, and immune rea...

journal_title：Experimental hematology

authors： Weiden PL,Storb R,Lerner KG,Kao GF,Graham TC,Thomas ED

更新日期：1975-04-01 00:00:00